Ct and mr imaging of giant cell granuloma of the craniofacial. It usually presents as a purplishred soft tissue nodule consisting of multinucleated giant cells in. Central giantcell granuloma harvard school of dental. Treatment of central giant cell lesions using bisphosphonates with intralesional corticosteroid injections. Peripheral giant cell granuloma is a common benign and reactive gingival epulis in oral cavity.
Pdf the central giant cell granuloma cgcg is an uncommon benign bony lesion that. Central giant cell granuloma venkateshwarlu et, al 6. Management of central giant cell granuloma of the jaws with. The referring doctor had suggested a diagnosis of eruption cyst. The central giant cell granuloma is an uncommon, benign and proliferative lesion whose etilogy is not well defined. Central giant cell granuloma cgcg is a benign, proliferative, intraosseous and nonodontogenic lesion of unknown etiology. Aggressive central giant cell granuloma occurring as peripheral one is a very rare case and the treatment of aggressive central giant cell granuloma with curettage has shown a high recurrence rate within a. Surgically treated central giant cell granuloma in sixyearold. Pdf central giant cell granuloma is an uncommon, benign, and proliferative lesion whose.
Central giant cell granuloma cgcg is a benign bone lesion which can be locally aggressive or may be asymptomatic in nature. The central giant cell granuloma cgcg was first described by jaffe in 1953 as a giantcell reparative granuloma of the jaw bones. They result from a local inflammatory process, thought to be secondary to trauma. Jul 20, 20 central giant cell granuloma cgcg is a relatively uncommon benign bony lesion of a variably aggressive nature, accounting for less than 7% of all benign jaw lesions. Medical school giant cell temporal arteritis made easy duration. The traditional treatment of cgcg of the jaws has been surgical excision either by curettage or enbloc resection,depending on following factors.
Pdf central giant cell granuloma of mandible mohit. Diagnosis of central giant cell granuloma is normally made histologically from an incisional biopsy. Aggressive central giant cell granuloma mimicking peripheral. Giant cell granulomas gcgs of the jaws are lesions that arise either peripherally in periodontal ligament, mucoperiosteum, or centrally in the bone. The treatment of the cgcg ranges from curettage to resection. We describe our experience in managing this lesion by intralesional triamci. The purpose of this study was to determine the ct characteristics and describe possible mr imaging features of gcg. Central giant cell lesions granulomas, also known as giant cell reparative cystsgranulomas, occurs almost exclusively in the mandible, although cases in the skull and maxilla have been reported.
It was first described as central giant cell reparative granuloma by jaffe h l in the year 1953. Central giant cell granuloma cgcg is an uncommon, benign, proliferative, and nonodontogenic lesion whose etiology is not defined. The referring doctor had suggested a diagnosis of eruption. Jun 19, 2018 the peripheral giant cell granuloma has an unknown etiology, with some dispute as to whether this lesion represents a reactive or neoplastic process. The first description of this tumor was presented by jaffe and recommended surgical management for these lesions. Peripheral giant cell granuloma or so called giant cell epulis is the most common oral giant cell lesion. Central giant cell granuloma cgcg is an intraosseous lesion which occurs as an uncommon benign condition in jaws. Giant cell granulomas occurring within the bone are called central giant cell granuloma cgcg and those occurring on edentulous. Combined management of large aggressive central giant cell. Katz, giant cell reparative granuloma outside the jaw bone.
Central giant cell granuloma cgcg is a benign aggressive destructive osteolytic lesion of osteoclastic origin. The central giant cell granuloma, also known as cgcl or giant cell lesion, was first described by jaffe in 1953. The case reported here resembled a wide variety of conditions that led to a misdiagnosis both on clinical and radiographic examination but was. Some, however, consider it to be a giant cell tumor occurring in both benign and. Surgical treatment such as simple curettage, simple curettage.
The appearance is generally distinctive with multinucleated giant cells. Clinically and radiologically, a differentiation between aggressive and nonaggressive lesions can be made. May 24, 2011 giant cell granuloma pptx dentalarchieve. Central giant cell granuloma is an uncommon benign intraosseus lesion of jaws.
The central giant cell granuloma cgcg is considered a benign, nonneoplastic lesion of bone found in a younger age group who are usually less than 30 years of age. The nuclei arranged either peripherally langhanstype giant cell or haphazardly foreign bodytype giant. This is in contrast to the giant cell tumor of long bones, where. Management of central giant cell granuloma of the jaws. Traditional treatment has been local curettage, although aggressive subtypes have a high tendency to recur. Peripheral giant cell granuloma pgcg is an oral pathologic condition that appears in the mouth as an overgrowth of tissue due to irritation or trauma. A central giant cell granuloma is a type of bone lesion that appears along the jaw. Central giant cell lesion cgcl is a benign lesion which has unpredictable biologic behaviour and is amenable to a plethora of treatment alternatives. It is a noncancerous condition that is usually painless, but irritation and open lesions in the mouth can lead. Central giant cell granuloma cgcg, formerly called giant cell reparative granuloma, is a nonneoplastic proliferative lesion of unknown etiology.
We report the results of the intralesional steroid injections for the management of central giant cell granuloma cgcg of the jaws. Oct 19, 2015 we report the results of the intralesional steroid injections for the management of central giant cell granuloma cgcg of the jaws. This peripheral giant cell granuloma involved the maxillary gingiva associated with an erupting central incisor of a 6yearold girl. Reactive gingival mass resembling pyogenic granuloma, which pushes teeth aside and may erode alveolar bone or involve periodontal membrane arises from periodontal ligament enclosing. We herein describe an intriguing case of a 21yearold male patient who was. It is a noncancerous condition that is usually painless, but irritation and open lesions in the mouth can lead to an infection and uncomfortable swelling.
It usually presents as a purplishred soft tissue nodule consisting of multinucleated giant cells in a background of mononuclear stromal cells and extravasated red blood cells. Chronic granulomatous inflammation linkedin slideshare. Peripheral giant cell granuloma is an infrequent reactive, exophytic lesion of the oral cavity, also known as giantcell epulis, osteoclastoma, giant cell reparative granuloma, or giant cell hyperplasia. Radiologic features, including those seen with computed tomography, of central giant cell granuloma of the jaws. Who defines this intraosseous lesions as a lesion that contains multiple foci of. Who has defined it as an intraosseous lesion consisting of cellular and fibrous tissue that contains multiple foci of hemorrhag slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. May 16, 2014 educational video created by unmc college of dentistry class of 2016 dental students. Giant cell granulomas are benign intraosseous lesions, typically occurring in young females. Aggressive central giant cell granuloma occurring as peripheral one is a very rare case and the treatment of aggressive central giant cell granuloma with curettage has shown a high recurrence rate within a span of six months, but in our case even after one year followup, no recurrence of the lesion was noticed. Epithelioid cells fuse to form giant cells containing 20 or more nuclei. Although there is not enough evidence that this lesion promotes reparative process, it was denominated reparative giant cell granuloma 2, 2530.
The nuclei arranged either peripherally langhanstype giant cell or. Central giant cell granuloma cgcg is an uncommon, benign, and. The incidence in the general population is very low and patients are generally younger than 30 years. It is twice as common in females and is more likely to occur before age 30. A clinical, radiologic and histopathologic study of 26 cases ooo 2006.
The condition was first identified in 1953 by jaffe, who initially termed this lesion as a central giant cell reparative granuloma, but nowadays the reparative word has been. Because of its overwhelming incidence on the gingiva. Extremely aggressive behavior of central giant cell granuloma. Central giant cell granuloma cgcg is a benign lesion of the jaws with an unknown etiology. Central giant cell granuloma cgcg is an uncommon benign bony lesion. Granuloma annulare articles case reports symptoms treatment, uk. Central giant cell granulomas are more common in the anterior mandible, often crossing the midline and causing painless swellings. Central giant cell granuloma cgcg is a relatively uncommon benign bony lesion of a variably aggressive nature, accounting for less than 7% of all benign jaw lesions. Central giant cell lesions granuloma dr yuranga weerakkody and assoc prof frank gaillard et al. Pathology outlines peripheral giant cell granuloma. Achieving the correct diagnosis is reportedly difficult because cgcgs are very similar to odontogenic jaw tumors. Ppt granulomatous inflammation powerpoint presentation. Interventions for central giant cell granuloma cgcg of the jaws source. Central giant cell lesions granulomas, also known as giant cell reparative cystsgranulomas, occurs.
We describe our experience in managing this lesion. Doctors do not fully understand what causes these lesions to. The case report is of a 30 year old male, who complained of a slowly expanding swelling in the maxilla in the left premolar region. Who defines this intraosseous lesions as a lesion that contains multiple foci of haemorrhage, consisting of cellular fibrous tissue and there is trabeculae of woven bone. Central giant cell granuloma of the anterior maxilla. Central giant cell granuloma, benign jaw tumor, molar, recurrent pericoronitis, multinucleated giant cells. Central giant cell granuloma is a benign, proliferative, intraosseous and non odontogenic lesion of unknown etiology. Full text pimary hyperparathyroidism as central giant.
Because of its overwhelming incidence on the gingiva, the condition is associated with two other diseases, pyogenic granuloma and peripheral ossifying fibroma. The purpose of this study was to determine the ct characteristics and describe possible mr imaging features of gcg of the craniofacial bones. Surgery is considered the best course of treatment. The more aggressive type may cause root divergence and destruction of the surrounding bone that expand the cortical plate. These tumors become severely invasive with the stimulus of surgery, resembling. Case report giant cell granuloma of the maxilla usman haider uzbek, iram mushtaq oral and maxillofacial unit, department of dentistry, ayub medical college, abbottabad. Reactive gingival mass resembling pyogenic granuloma, which pushes teeth aside and may erode alveolar bone or involve periodontal membrane arises from periodontal ligament enclosing root of tooth central giant cell granuloma.
Central giant cell granuloma was 1st described in jaws by jaffe 1953. Peripheral giantcell granuloma pgcg is an oral pathologic condition that appears in the mouth as an overgrowth of tissue due to irritation or trauma. Also called giant cell reparative granuloma central if intraosseous. The term giant cell reparative granuloma gcrg was first used by jaffe in 1953. It was jaffe who first introduced the term central giant cell reparative granuloma to distinguish this lesion from the giant cell tumor of long bones.
Although there is not enough evidence that this lesion promotes. Central giant cell granuloma cgcg is a benign intraosseous lesion that occurs in long. Histologically, both peripheral and central giant cell granuloma cgcg are characterized by the presence of numerous multinucleated. Educational video created by unmc college of dentistry class of 2016 dental students. Full text pimary hyperparathyroidism as central giant cell. But the term reparative is obsolete, as cgcg causes the destruction of involved bones. The appearance is generally distinctive with multinucleated giant cells spread throughout the lesion but often focal in distribution around areas of possible hemorrhage figure 4.
These tumors become severely invasive with the stimulus of surgery, resembling malignant tumors. These giant cells can be found either at the periphery or the center of the granuloma. However, most authorities believe peripheral giant cell granuloma is a reactive lesion. Giant cell reparative granuloma, central definition of. In 1953, jaffe described it as reparative granuloma of jaw bones. Aggressive central giant cell granuloma of the mandible, a. Jun 19, 2018 this peripheral giant cell granuloma involved the maxillary gingiva associated with an erupting central incisor of a 6yearold girl. It is often difficult to make a clinical diagnosis. The diagnosis and management of giant cell lesions of the jaws. Recurrent central giant cell granuloma in the mandible. Although central giant cell granulomas cgcgs appear to be benign, their radiographic findings are active. Central giant cell granuloma cgcg is a localised benign condition of the jaws. May 02, 2020 a central giant cell granuloma is a type of bone lesion that appears along the jaw. Seven cgcgs were treated with intralesional injection of corticosteroids.
Extremely aggressive behavior of central giant cell. Due to these lesions often being symptomatic, active management is usua. Apr 17, 2015 central giant cell granuloma was 1st described in jaws by jaffe 1953. Seven cgcgs were treated with intralesional injection of.
Granuloma annulare uk pdf ppt case reports symptoms. Central giant cell lesions the central giant cell granuloma, also known as cgcl or giant cell lesion, was first described by jaffe in 1953. The first description of this tumor was presented by jaffe and recommended. Central giantcell granuloma cgcg is a localised benign condition of the jaws. Central giant cell lesions granuloma radiology reference. Central giant cell granuloma is a rather rare lesion of the jaws aetiology of which is.
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